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Confirmarea unui diagnostic de MI acută cu EBV este dată, în general, de un rezultat pozitiv al testului pentru anticorpi heterofili. Pe de altă parte, diagnosticul ridică dificultăți atunci când。

Anticorpii heterofili sunt absenti in 10-20% din cazurile de mononucleoza infectioasa la adult, procentul fiind mai mare la copiii cu infectie manifesta. In aceste situatii, confirmarea。

Anticorpi anti-antigenul precoce (Anti-Eanticorpi heterofiliA, Early Antigen) Anticorpi anti-antigenul nuclear EBV (EBNA, EBV Nuclear Antigen) CDC nu mai recomanda folosirea in practica。

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